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Contraindicated (1)pentobarbital will lessen the level or result of dienogest/estradiol valerate by influencing hepatic/intestinal enzyme CYP3A4 metabolism. Contraindicated. Gals should not pick out estradiol valerate/dienogest as their contraceptive although using sturdy CYP3A4 inducers on account of prospective minimize in contraceptive efficacy.